Abstract

FLASH DISSOLVING ALMOTRIPTAN MALATE ORAL DISINTEGRATING TABLETS FOR MANAGEMENT OF MIGRAINE

Udaykumar B. Bolmal*, Manojkumar C. and Rajashree S. Masareddy

Abstract

The present study was aimed to formulate flash dissolving Almotriptan malate oral disintegrating tablets for management of migraine using direct compression method. Almotriptan malate was highly selective serotonin 5-HT1B/1D receptor agonist used in the treatment of migraine. Almotriptan malate belongs to BCS class III drug i.e. High Solubility and Low Permeability. The Bioavailability is 69.1% somewhat limited after oral dosing so parenterals dosing is an alternative choice but it causes inconvenience to patients so an attempt was made to formulate oral disintegrating tablets in order to enhance the bioavailability All the formulations were subjected to precompression and post- compression parameters. The powder blend showed good flow properties for all the formulations. All the formulated tablets were found within the permissible limits for pre and post- compression parameters. F10 is considered has optimized formulation containing combination of 7.5% concentration of crospovidone and fenugreek mucilage powder showed maximum drug release of 98.05 % at the end of 14 mins. Among all the formulations F10 containing higher amount of crospovidone and fenugreek mucilage powder have hardness 2.80 kg/cm2, friability 0.075%, drug content 98.05%, thus fulfilling all the parameters. It has shown least disintegration time 21.25±0.240 sec as compared to other formulations. All the ten formulations showed that disintegration time were less than 50 secs. This indicates rapid disintegration, water absorption ratio showed good absorptive in all the formulations. F10 formulation was compared with selected F6 and F9 and results revealed that F10 showed good in-vitro drug release study. Stability studies were carried out at room temperature and accelerated temperature, results revealed that at room temperature F10 formulation was stable. By this study we concluded that combination of natural and synthetic super disintegrating agents shows synergistic effect by increasing in vitro dissolution rate.

Keywords: Almotriptan malate, Direct compression method, Super disintegrants, ODT, in-vitro drug release study.