Abstract

FORMULATION AND EVALUATION OF THE PERIODONTAL GEL FOR PEDIATRIC USE WITH AN OBJECTIVE OF INCREASING RESIDENCE TIME OF DRUG

Yadav M. Bayakewar*, Sagar C. Kamble, Triveni M. Pusane, Dr. Dinesh M. Biyani, Dr. Milind J. Umekar

Abstract

Periodontal gel formulations are currently a novel idea of delivering drugs to patients, yet achieve sustained release of drug for the desired period. Different delivery systems based on polymers have been developed, which are able to increase the residence time of the formulation at absorption site of drugs. The most important approach for periodontal treatment is the control of inflammation. Pain management has always been an important part of dental care. Therefore, the main categories of drugs to be used in such conditions are analgesics and anti-inflammatory agents. Also from the point of view that periodontal diseases have their origin in some form of infection. So it is worthwhile to use one of the antibiotics also. Considering the gelling property of Carbopol 940 is used as a gelling agent, an attempt was made to develop gel system for dental use. Chitosan was incorporated for sustained release action. Metronidazole, Clindamycin, Doxycycline and Serratiopeptidase, as antibiotics and anti-inflammatory agents were the choice of drugs.

Keywords: Periodontal gel, dental care, analgesics and anti-inflammatory, Carbopol 940, sustained release, Metronidazole, antibiotics.