Abstract

MAIN METHODS OF SYNTHESIZING ISONIAZID IN LABORATORY

Rutuja T. Jadhav* and Yashvardhan P. Bhosale

Abstract

Isonicotin hydrazine (INH) known as isoniazid is a first-line antituberculosis drug. The main methods to synthesize this compound in the lab are: the reaction of isonicotinic acid and hydrazine and the reaction of isonicotinic acid ester and hydrazine. The recommended method for obtaining isoniazid is isonicotinic acid with hydrazine because the reaction temperature is low and the purification is done easily. In the laboratory syntheses were conducted to determine the best reaction conditions for the synthesis of isoniazid. In terms of duration synthesis is observed that with increasing reaction time the yield increases but the most convenient time interval is two hours.

Keywords: Tuberculosis, isonicotinic acid, hydrazine, isonicotinic acid ethyl ester, air oxidation, oxidation with ozone, electrolysis method.