Abstract

ANTI-STAPHYLOCOCCAL COMPARATIVE STUDY OF SYZYGIUM POLYANTHUM [WIGHT.] WALP. LEAVES EXTRACT

Sri Agung Fitri Kusuma*, Rizal Zam’an and Irma Erika Herawati

Abstract

Objective: This aim of this study was to compare the antistaphylococcal potency of Syzygium polyanthum [Wight.] Walp leaf ethanolic extract against neomycin sulfate as antibiotic standard. Methods: The test was carried out by determining the potency of the extract and the neomycin sulfate to generate the same inhibition against S. aureus. The data of inhibition diameters were obtained from the result of the agar diffusion method. The obtained diameters were plotted against the log of the use concentration and inhibition curves of both tested agent were produced . The line equation from each curve was used to determine the concentration of each tested agent in resulting the same diameter of inhibition. Both concentrations then used to calculate the comparative value by dividing the concentration of the extract with the neomycin sulfate. Results: The anti-staphylococcal potency of neomycin sulfate was stronger than the S. polyanthum leaf extract. The comparative value of the neomycin sulfate against the extract was 1: 32,474.92679. Conclusion: The leaf extract of S. polyanthum is a promising natural agent to be an anti- staphylococcal candidate.

Keywords: comparative, Syzygium polyanthum [Wight.] Walp, Staphylococcus aureus, potency, neomycin sulfate.