Abstract

SAFETY PROFILE OF SEENTHIL CHOORANAM ON REPEATED DOSE 90 DAYS ORAL TOXICITY STUDY IN WISTAR ALBINO RATS

S. Ushakanthan*

Abstract

The drug Seenthil Chooranam has been mentioned in the classical siddha text Agasthiyar Paripuranam – 400 (for Megam (Diabetic mellitus), Eelai (Tuberculosis), Kasam (Cough), Elaipu (Bronchial asthma), Eranda vayu (Scrotal swelling). The drug Seenthil Chooranam is prepared by mixture of herb and the animal product. In repeated dose of 90 days oral toxicity study results, all animals from the treated dose survived throughout the dosing period of 90 days. Animals from treated groups and control group shows overall weight gain throughout the study period of 90 days. The haematological and biochemical results shows no significant changes. But sugar levels were reduced significantly when compare to the control group, At the end of the study gross pathological examination of animals in control and treated groups did not reveal any abnormalities. The vital organs as liver, heart, kidneys, lungs and brain from the test group did not reveal any abnormal macroscopic changes. Gross pathological investigation was carried out and histopathology of vital organs revealed normal histological appearance when compared with the control group.

Keywords: Siddha Medicine, Toxicity and Seenthil Chooranam.