Abstract

CHEMICALLY MODIFIED TETRACYCLINES: A REVIEW

Dr. Suchetha A., Dr. Surya Suprabhan*, Dr. Sapna N., Dr. Divya Bhat and Dr. Darshan B. M. and Dr. Rameshwari B.

Abstract

Periodontitis is a microbial infectious disease that causes loss of supporting tooth structures. Host-microbial interaction can aggravate the destruction of periodontium. Hence host modulatory agents such as tetracycline and its derivatives like Chemically Modified Tetracyclines (CMTs) have been proposed. CMTs lack antimicrobial action but have anti-collagenase activity. CMTs reduce the MMP production and also reduce the amount of proinflammatory cytokines produced. They do not cause antibiotic resistance unlike tetracycline. Hence, CMTs are considered to be one of the potent host modulation agents that can be used for treatment of periodontitis.

Keywords: Periodontitis, MMPs, Tetracyclines.