Abstract

GASTRORETENTIVE MUCOADHESIVE DRUG DELIVERY SYSTEM

Pooja R. Hatwar* and Dr. M. A. Channawar

Abstract

Oral drugs delivery is most preferable route of drug delivery for administration of therapeutic agents. Gastro retentive drug delivery system in which dosage forms that can be reserved in stomach and mucoadhesives enhances the efficiency of drug delivery. Gastroretentive mucoadhesive drug delivery system have been developed to expands drug bioavailability by prolonging gastric retention time, reduce drug waste, and improve the drugs solubility that are not easily soluble in high pH environment of small intestine by use of mucoadhesive polymer. For gastro retentive mucosal adhesion drug delivery system the article exemplify the mechanism by which mucoadhesion can be adhere to a mucous membrane with respect to the nature of the adhering surfaces and the forcing to generate intimacy between them. There are many factors that affect gastric retention and mucous membrane adhesion.

Keywords: Gastroretentive drug delivery system; mucoadhesive system, Theories, Factors, Polymers.