Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF REPAGLINIDE PRONIOSOMAL GEL FOR TRANSDERMAL DELIVERY

Satheesha A. P.*, Parthiban S. and Senthilkumar G. P.

Abstract

The aim of the present study is to formulate and evaluate Proniosomal gel formulations as transdermal delivery systems of Repaglinide to improve its therapeutic effect in a controlled manner. A 2x 2factorial design have been applied for optimization, by varying surfactant and soyalecithin concentration. All the formulations were evaluated for various parameters such as vesicle size analysis, surface morphology, zeta potential, pH, stability studies. The result shows that the span40(SF4) have better Entrapment efficiency (96.23±0.8) and also high % drug content (95.68±0.5) compare to Span60, it is evident that Span40 is better suitable surfactant to enhance the bioavailability and better therapeutic effect of Repaglinide loaded Proniosomal gel through transdermal drug delivery system.

Keywords: Proniosomal gel of Repaglinide, Transdermal delivery, Antidiabetic, 2 X 2 factorial design.