Abstract

FORMULATION AND DEVELOPMENT OF SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS) OF FLURBIPROFEN

*Jawad A., Intan F. S., Jiyauddin K., Asbi A., S. Budiasih, M. Kaleemullah and Samer A. D.

Abstract

A selfmicro-emulsifying drug delivery system (SMEDDS) has beendeveloped to enhance diffusion rate and oral bioavailability ofFlurbiprofen. The solubility of Flurbiprofen was checked in differentoils, surfactants, and co-surfactants and ternary phase diagrams wereconstructed to evaluate the micro-emulsion domain. The FlurbiprofenSMEDDS was prepared using Capmul MCM (oil), Tween 80(surfactant), and polyethylene glycol 400 (co-surfactant). The particlesize distribution, zeta potential, and Polydispersity index weredetermined and found to be 12.3 nm, −0.746, and 0.138, respectively.Diffusion rate of Flurbiprofen was measured by In- Vitro dialysis bagmethod using phosphate buffer pH 6.8 as diffusion media. Developedhigh-performance liquid chromatography method was used todetermine drug content in diffusion media. Oral bioavailability ofFlurbiprofen SMEDDS was checked by using mice model. Results of diffusion rate and oralbioavailability of Flurbiprofen SMEDDS were compared with those of pure drug solution andof marketed formulation. Diffusion of Flurbiprofen SMEDDS showed maximum drug releasewhen compared to pure drug solution and marketed formulation. The area under curve andtime showed significant improvement as the values obtained were 607ng h/mL and 1 h for SMEDDS in comparison to 445.36 and 1.36 h for market formulation suggesting significantincrease (p<0.01) in oral bioavailability of Flurbiprofen SMEDDS.

Keywords: Flurbiprofen, Surfactant, Zeta Potential, Polydispersity Index and Bioavailability.