Abstract

THERAPEUTIC APPROACHES FOR OBSERVING THE ANTIINFLAMMATORY AND ANTI-NOCICEPTIVE EFFECTS OF GLYCYRRHIZIN AND KETOROLAC IN CFA-INDUCED INFLAMMATORY PAIN IN MICE

Kedar S. Prabhavalkar* and Ayesha Mulla

Abstract

Inflammatory mediators and cytokines are responsible for the inflammatory pain responses and their inhibition represents as the therapeutic approach in controlling chronic pain. Glycyrrhizin and ketorolac act as anti-inflammatory and anti-nociceptive. In this present study, the combination of both the drugs are used as the treatment for inflammatory pain. Male Swiss mice were treated with this combination after the 24hours of CFA (Complete freunds adjuvant) induction. CFA is used as inducer in mice for inflammatory pain model. Both these drugs inhibit the mechanical and thermal hyperalgesia. Glycyrrhizin is used to block the High Mobility box protein-1 (HMGB1) and Ketorolac acts on the Transient receptor potential vanilloid-1 (TRPV1) receptors thus they further block the inflammatory pathway. Indomethacin is used as a standard and it is the most used Non-steroidal anti-inflammatory drugs (NSAIDS). Indomethacin when used for prolonged time, might cause gastric injury. So, the new treatment must come into picture for treating the inflammatory pain.

Keywords: Inflammatory pain, Complete freunds adjuvant, HMGB1, TRPV1.