Abstract

A REPORT OF FIVE CASES OF FLUOROQUINOLONE-INDUCED EPIDERMAL NECROLYSIS AT A TERTIARY CARE TEACHING HOSPITAL IN NORTHERN KARNATAKA

Bhandarkar Anoosha P, Kop Priyadarshini B, Pai Varadraj and Navin A Patil

Abstract

Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are life-threatening, epidermal necrolytic adverse drug reactions (ADRs) considered to be within a spectrum of severe exanthematous vesico-bullous disorders, mostly attributable to drugs like anticonvulsants, NSAIDS and antimicrobials. Lately, the reports on Fluoroquinolone (FQ) induced SJS/TEN are rising. Our retrospective study conducted in this direction, brings in five such cases which manifested with severe epidermolyticmucocutaneous lesions after taking oral FQ therapy for gastrointestinal/ respiratory/genito-urinary indications. With the dechallenge of offending agents and adequate management of patients‟ clinical condition, four of them improved but the immunocompromised patient with TEN died despite intensive systemic corticosteroid and I.V-immunoglobulin therapy.

Keywords: Stevens-Johnson syndrome, Toxic epidermal necrolysis, vesico-bullous disorders.