Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL LIGAND( DIETHYL 5-AMINO 4-METHYL THIOPHENE 3,5-DICARBOXYLATE-2,6-DIAMINOPYRIDINE) AND ITS METAL COMPLEXES

*Dr.Mohammed.Fakruddin Ali Ahamed, Kassahun Desalegn Gebremariam

Abstract

Metal complexes of Cu (II) and Hg (II) with a new Schiff base derived from Diethyl 5-amino 4-methyl thiophene 3,5-dicarboxylate-2,6- Diaminopyridine(DAMTDDAP) in methanol are reported. The complexeshave been characterized using chemical analysis, (IR, UVVIS, H1-NMR), conductometric data. According to these data, we propose an octahedral geometry for metal (II) complexes. The invitro antibacterial activities of the investigated complexes were evaluatedagainst few microorganisms by well diffusion technique. It was found that the metal complexes havehigher activity that the standard drugs. Antibacterial activity of the ligand and its complexes werestudied against to gram positive bacteria; Staphylococcus aureus and bacteria Salmonella typhi , Pseudomonas aureginosa and Escherichia coli.

Keywords: Hexa-dentate Schiff base, Diethyl 5-amino 4-methyl thiophene 3,5- dicarboxylate-2,6-Diaminopyridine(DAMTDDAP), Biological activity.