Abstract

PHARMACOGNOSTICAL AND PHARMACEUTICAL EVALUATION OF ASHTAMANGALA GHRITA IN THE MANAGEMENT OF ATTENTION -DEFICIT /HYPERACTIVITY DISORDER (ADHD) IN CHILDREN

Kingsila Manohari*, Prof. K. S. Patel, Dr. V. K. Kori, Harisha C. R. and Shukla V. J.

Abstract

Background: ADHD is the most common neurobehavioral disorder of childhood which affects 5% of Children all over the world. Ashtamangala Ghrita is an Ayurvedic polyherbal drug was used as Nasya and it proved its efficacy and safety in Highly significant and significant results in the management of symptoms of ADHD according to DSM-V in children by acting on Manas and Buddhi in Manovaha Srotasa. Aim: to setting a standard authentication profile for Ashtamangala Ghrita by Pharmacognostical & Pharmaceutical parameters. Materials & Methods: Ashtamangala Ghrita was prepared as per classical methods and the drug was subjected to Organoleptic analysis, Powder microscopical analysis, physicochemical analysis and High performance Thin Layer Chromatography (HPTLC) examination. The final observations were systematically recorded. Results: Organoleptic evaluation of coarse powder made out of the crude drugs, were within the standard range as per mention in classics. The powder Microscopy evaluation revealed that, diagnostic character of Vacha showed Oleoresin content & Starch grains. Kushta showed Compound starch cells. Brahmi showed Pollen grains, Parenchymal cells along with oil globules & Fiber cells. Siddharthaka showed Epicarpal cells & Parenchymal cells along with oil globules. Sariva showed Brown tannin content, Fiber cells, Simple starch grain with hilum & Rhomboidal crystal. Pippali showed Stone cells. Physicochemical evaluation of finished drug showed, Acid Value 2.889, Saponification value 142.708, Iodine value 31.07, Specific gravity 0.9076 and Refractive index 1.4730. High Performance Thin Layer Chromatography (HPTLC) showed 11 spots at 254 nm and 06 spots at 366 nm. Conclusion: The Results obtained could be utilized as references standard for quality assurance of Ashtamangala Ghrita in the management of ADHD.

Keywords: Attention –Deficit/ Hyperactivity Disorder (ADHD), DSM-V, Ashtamangala Ghrita, Pharmacognocy, Pharmaceutics, HPTLC.