Abstract

AMELIORATION OF CISPLATIN-INDUCED TOXICITY IN EXPERIMENTAL ANIMALS BY BAICALIN

Tushar Sawant* and Kedar Prabhavalkar

Abstract

Introduction: Cisplatin is associated with serious adverse events which overshadowed its efficacy. Baicalin found to reduce the cisplatin-induced cytotoxicity and renal damage in animal models. The aim of the current study is to demonstrate protective effect of baicalin in cisplatin-induced toxicity models in mice. Methods: Healthy Swiss Albino mice (weight range of 20-30 g), after acclimatization divided into 8 groups (n=8): normal control, vehicle control, baicalin (50 mg/kg), cisplatin (7 mg/kg), quercetin (50 mg/kg) + cisplatin, baicalin (40, 80, and 120 mg/kg) + cisplatin. For induction of cisplatin toxicity model, cisplatin (7 mg/kg) was administered from day 11 to 15 of study period. Baicalin was administered at 40, 80, and 120 mg/kg for 15 days. On 16th day, blood samples were collected and mice were sacrificed to excise kidneys and livers. Results: In cisplatin treated group, blood urea nitrogen, creatinine, serum glutamic pyruvic transaminase, and serum glutamic-oxaloacetic transaminase levels were significantly (P

Keywords: Baicalin; cisplatin; cisplatin-induced toxicity; nuclear factor erythroid 2– related factor 2; tumor necrosis factor alpha.