Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF DASTINIB NASOSPONGES

Velicharala Srilakshmi*, Ch. Saibabu, K. Thejomoorthy and P. Sreenivasa Prasanna

Abstract

In this study, Nanosponges of Dasatinib was prepared by the solvent evaporation technique. The Nanosponges formulations were prepared by solvent evaporation method employing Ethyl Cellulose, β Cyclodextrin and poloxamer as rate retarding polymers using PVA as a copolymer. The compatibility of the Drug with formulation components was established by Fourier Transform Infra-Red (FTIR) spectroscopy. The surface morphology, production yield, and drug entrapment efficiency of Nanosponges were examined. The Shape and surface morphology of the Naanosponges were examined using scanning electron microscopy. Scanning electron microscopy revealed the porous, spherical nature of the Nanosponges. SEM photographs revealed the spherical nature of the Nanosponges in all variations; however, at higher ratios, drug crystals were observed on the nanosponge surface. Increase in the drug/polymer ratio (1:1 to 1:3) which is in increasing order due to the increase in the concentration of polymer. However, after a particular concentration, it was observed that as the ratio of Drug to polymer was increased, the particle size decreased. The particle size was found in the range of 200- 500 nm. The entrapment efficiency of different formulations were found in the range of 91.56 to 99.12%, By comparing the above dissolution studies of formulations F1-F9. Maximum drug release was found in F6 formulation containing Drug: β-cyclodextrin in 1:3 ratio. So F6 formulation was taken as the optimized formulation, and drug release kinetics were performed and which follows zero-order kinetics with super case II transport mechanism.

Keywords: Dasatinib, ?-Cyclodextrin, Poloxamer, Ethyl Cellulose, Nanosponges Delivery System (NDS). Scanning Electron Microscopy (SEM).