Abstract

FORMULATION AND EVALUATION OF FLUCONAZOLE EMULGEL BY USING DIFFERENT POLYMERS

Maneesh Banyal*, Swati Joshi, Antariksh Kumar Arya and Abdul Faruk

Abstract

In present work, emulgel of fluconazole were prepared by using two polymers Carbopol 940 and Guar-Gum as a gelling agent. Fluconazole is hydrophobic and emulgel has potential, which makes it the most suitable delivery system for hydrophobic drugs. In the preparation of fluconazole emulgel, light liquid paraffin used as an oily phase in different concentrations, and an emulsifying agent such as Tween 20 and Span 20 were used. All the prepared emulgel formulation were analyzed for FTIR analysis for the compatibility of drug and excipients. Further, all the formulation evaluated for their pH, physical properties, spreadability, phase separation, stability study, and in-vitro permeation study. By all the results it was observed that formulation F2 shown the highest drug content and highest drug release and formulation F3 shown good spreadability because in these formulation carbopol 940 is used and while Guar-gum emulgel formulation F5 showed highest drug content and highest drug release respectively.

Keywords: Emulgel, Gelling agents, Carbopol-940, Guar-Gum, In-vitro permeation.