Abstract

FORMULATION AND EVALUATION OF IN-SITU GELLING SYSTEM FOR SUSTAINED RELEASE OPHTHALMIC DRUG DELIVERY OF CIPROFLOXACIN

Ashish Singh*, Seema Kurkure and Sonali Anardi

Abstract

Delivering drugs to ocular region is a challenging task. Eye physiological barriers lead to relatively less therapeutic and bioavailability effect by the conventional eye drops. This may be overcome by the use of in situ gel delivery system. Objective: The objective of our work was to formulate an ocular delivery system of Ciprofloxacin, based on the concept of ion (sodium alginate) activated in situ gelation concept. Due to its elastic properties, insitu gels resist the ocular drainage of drug leading to longer contact times with ocular surface. The major drawback of the eye drops is rapid elimination of drug from the precorneal region, thus ensuing poor bioavailability as well as therapeutic efficacy. To conquer these limitations, in situ gel was developed for sustained delivery of Ciprofloxacin. Two polymers namely hydroxypropyl methylcellulose (HPMC) and sodium alginate were used to formulate the in-situ gel.

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