Abstract

FORMULATION AND IN VITRO EVALUATION OF HYDROGEL NIZATIDINE TABLETS

R. Sunitha*, M. Lakshmi Surekha, R. Padma and G. Rajesh

Abstract

Hydrogels were originally developed as novel drug delivery system to retain drugs in the gastric medium. These systems should instantly swell in the stomach and maintain their integrity in the harsh stomach environment, while releasing the pharmaceutical active ingredient. The present review focuses on concept of development of Nizatidine as hydrogel tablets, their applications and various evaluation technique. The aim of this study is to prepare Gastro retentive dosage form based on SPH using a model drug Nizatidine for swelling & prolonged drug release characteristics in acidic pH. The formulation is based on preparation of third generation hydrogels with three different polymers, such as, Sodium alginate, Hydroxy ethyl cellulose, Chitosan, PVPK30. were used with different concentrations by cross linking technique to get the desired sustained release profile over a period of time. The characterization studies for hydrogels, were performed by measurement of apparent density, porosity, swelling studies, mechanical strength, and FT-IR. All formulations were evaluated for stability, drug content and kinetic drug release & in-vitro drug release profile.

Keywords: Gastro retentive dosage forms, hydrogels, chitosan, swelling, Nizatidine.