Abstract

EFFECT OF REPAGLINIDE, A P-GLYCOPROTEIN MODULATOR ON ABSORBTION OF PHENYTOIN

Stephen I. and Vimalavathini R.*

Abstract

P-glycoprotein, an efflux transporter prevents intracellular accumulation of toxins and xenobiotics. The present research work aims to investigate the effect of repaglinide on absorption of phenytoin due to the evidence of repaglinide having affinity for P-glycoprotein. The objective of the study was to assess apparent permeability coefficient of phenytoin in the presence of repaglinide by non-everted sac technique. The results of ex-vivo study showed that phenytoin level decreased in a time and dose dependent manner ascertaining the inducing role of repaglinide on P-glycoprotein leading to the decrease in concentration of phenytoin which may lead to therapeutic failure. Hence this combination may require close monitoring for better therapeutic outcome.

Keywords: P-glycoprotein, an efflux transporter prevents intracellular accumulation of toxins and xenobiotics.