Abstract

DESIGN AND CHARACTERIZATION OF ZANAMIVIR LOADED NIOSOMES

Amar Shripati Kulkarni*, Amol Nivas Jadhav, Chandrashekhar Vishnu Babar, Samar Rangrao Patil, Nikhil Dilip Mirajkar, Swati Dhanaji Jadhav

Abstract

In the present study, we explored the potential of Zanamivir loaded Niosomes, as a new formulation in improving the bioavailability of Anti-influenza drug Zanamivir. The Zanamivir loaded niosomes was prepared by using “Thin Film Hydration Method”. A 32 full factorial experiment was designed to study the effect of independent variables such as lipid, surfactant and co-surfactant composition. The formulations were in the form of suspension. The mean particle size of Niosome measured to 160 to 360 nm with PDI value of 0.995 to 2.192, and zeta potential value of -12.05 to -21.14 mV was observed which indicates Niosomes formulations found to more stable. The entrapment efficiency was estimated to be 93.02 to 97.26%. SEM study shows Niosomes in spherical as well as irregular in shape. DSC and FTIR showed the molecular encapsulation of drug in the lipid matrix. The in-vitro release study shows that all formulations followed Zero Order Kinetic Model which implies that developed formulations have a potential to deliver the drug in controlled release manner. These finding explore the potential of proposed Niosomes of Zanamivir formulation as an alternative drug delivery system in improving bioavailability of Zanamivir.

Keywords: Influenza, Niosomes, Zanamivir, Poloxamer 407, Cholesterol, Controlled Release Action.