Abstract

CONDUCTANCE MEASUREMENTS OF MCM-41 AND TIO2-MCM-41 IN PRESENCE OF NICOTINAMIDE (A HYDROTROPIC AGENT) IN ETHANOL FOR PARTIALLY SOLUBLE DRUGS

Srabani Swagatika*, Suresh Kumar Dash and Upendra Nath Dash.

Abstract

The conductance measurements of MCM-41 and TiO2-MCM-41(10 and 15 weight %), have been measured in the concentration range of 40 ppm-140ppm in ethanolic solution of hydrotropic agent nicotinamide at different temperatures ranging from 298.15 K to 313.15 K at an interval of 5 K. The conductance data have been analyzed by Shedlovsky method to obtain Ʌ0 and KA. The thermodynamics parameters,such as change in enthalpy, entropy and free energy for the ion pair formation have been calculated from the value of ion association constant at constant temperature. The results have been discussed in terms of ion-ion, ion-solvent and solventsolvent interactions and also the effects of various substituents(groups) were investigated. This investigation gave detailed information regarding pharmakokinetics and pharmakodynamics of these drug carriers.

Keywords: TiO2-MCM-41, Ethanol, Nicotinamide,Association constant.