Abstract

METALLOCENE POLYMERS AS ANTIVIRIAL ZIKA VIRUS AGENTS FROM THE LEWIS BASES LAMIVUDINE AND CAMPHORIC ACID

Michael R. Roner*, Charles E. Carraher, Jr.*, Lindsey Miller, Jessica Frank, Francisca Mosca, Paul Slawek, Jerome E. Haky and Anthony Campbell

Abstract

The total inhibit of the zika virus is described. Because of the zika virus’s structural closeness it is considered a target virus for the inhibition of the current covid-19 virus. Two groups of polymers exhibited ability to totally inhibit the zika virus. These polymers are derived from group 4 metallocene dihalides and camphoric acid and lamivudine. This is the second report of complete inhibition of the zika virus and it is done using commercially available simple drugs. All the drugs described in these studies are rapidly (less than 30 seconds) synthesized at room temperature employing the interfacial reaction system that is employed industrially so that scale up to kilograms is relatively straight forward.

Keywords: Zika virus, group 4 metallocene polymers, lamivudine, camphoric acid, titanocene dichloride, zirconocene dichloride, hafnocene dichloride, organotin polymers.