Abstract

A REVIEW ON CONCEPT AND VIGILLANCE OF PULMONARY DRUG DELIVERY SYSTEM

Tejaswini S. Lohakare*, Dr. Archana D. Kajale, Dr. Madhuri A. Channawar, Dr. Shilpa R. Gawande

Abstract

Pulmonary drug delivery is primarily used to treat condition of the airways delivery locally acting drugs directly to their site of actions. Delivery of anti-asthmatic and other locally acting drug directly to their site of action reduces the dose needed to produce a pharmacological effect. While the low concentration in the systemic circulation may an also reduce the side effects, provide the rapid response and minimize the required dose since the drug is delivered directly to the conducting zone of the lungs is a needle free several technique have been developed. The overall drug delivery depends on its efficacy, quality, safety and to achieve such a attributes. New dispersible formulations and drug aerosol delivery devices for inhalable peptide, protein and various small molecules become of increasing interest for the treatment of systemic and respiratory diseases. The important requirement pulmonary delivery system is a provide perfect deposition of drug in lung this can be achieved by preparing optimum size of the particles. Pulmonary route as an Non-invasive administration for systemic delivery and therapeutics agents (mainly peptide and protein) due to the fact that the lungs could provide a large absorptive surface area but extremely thin (0.1μm and 0.2μm) absorptive mucosal membrane and good blood supply. Aerosol administration of peptidebased drug also play important role in the treatment of pulmonary and systemic disease and the unique cellular properties of airway epithelium offers a great potential to deliver new compounds. As the relative contribution from the large airways to large alveolar space are important availability. It’s a treatment of illness, asthma, include chronic obstructive pulmonary disease etc. which maximum patient comfort and compliance.

Keywords: Pulmonary drug delivery system, delivery devices, lungs, particles, airways, clearance, aerosol.