Abstract

NANOSUSPENSION: AN PROMISING APPROACH TO ENHANCE SOLUBILITY OF POORLY SOLUBLE DRUGS

Mohini E. Shinde*, Avish D. Maru, Mitesh P. Sonawane, Suvarna S. Vadje, Kajal R. Patil

Abstract

Solubility is a vital factor for developing drug delivery systems for poorly water soluble drugs. One of the major problems associated with poorly soluble drugs is very low bioavailability. The problem is even more complex for drugs like itraconazole, simvastatin and carbamazepine which are poorly soluble in aqueous and non aqueous media, belonging to BCS class II as classified by the biopharmaceutical classification system. Recently, nanoscale systems have received much interest as a way to resolve solubility issues because of their cost effectiveness and technical simplicity compared to liposomes and other colloidal drug carriers. Nanosuspensions have proven to be a better alternatives over other approaches currently available for improving bioavailability of number of drugs with low bioavailability. Formulation as nanosuspension is an attractive and promising alternatives to solve these problems. this review describes the preparation methods, formulation aspect, characterization, and applications of the nanosuspensions.

Keywords: Nanosuspension, Solubility, Bioavailability, Saturation solubility, Dissolution.