Abstract

APPLICATION OF THIOLATED CHITOSAN IN MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEM

Dhanashri P. Garud*, Kalyani Dalavi and Sagar Deole

Abstract

A mucoadhesive buccal film of chemically modified chitosan has been developed for controlled and prolonged drug delivery application. Chitosan is chemically modified through thiol bearing reagent leads to formation thiolated chitosan which improves mucoadhesivity. The purpose of this review article is to provide brief description of mucoadhesive buccal drug delivery system, followed by thiolated chitosan derivatives. The present article provides insights into various issues like anatomy of buccal mucosa, benefits of buccal films, theories of Mucoadhesion, thiolated chitosan derivatives and evaluation of buccal film.

Keywords: Mucoadhesion, chitosan, thiolated chitosan, disulfide bonds.