Abstract

FORMULATION AND EVALUATION OF CLOTRIMAZOLE LOADED TRANSDERMAL PATCH

Swati Joshi*, Maneesh Banyal and Dr. Abdul Faruk

Abstract

Clotrimazole possesses antifungal activity and have biological half life of two hours, and it has many gastro-intestinal side effects when administered orally. In present work to overcome these side effects the transdermal patch of clotrimazole were prepared by solvent casting method using three polymers Eudragit RS-100, Hydroxy methyl propyl cellulose (HPMC) and Ethyl cellulose (EC). Propylene glycol was used as penetration enhancer as well as plasticizer and methanol and dichloromethane were used as solvent in same concentration. Compatibility study for all the prepared patches were analyzed by FTIR spectrophotometer. All the prepared patches were evaluated for their weight variation, moisture content, folding endurance, thickness, drug content and in-vitro permeation study. Further prepared patches characterized for scanning electron microscopy. From the result it was concluded that combination of three polymers shows good physical properties and formulation F1 shows higher drug release as compared to formulation containing two polymers.

Keywords: Clotrimazole, Eudragit RS-100, HPMC, EC, In-vitro permeation study.