Abstract

EVALUATION OF ANTI-OBESITY AND ANTI-DIABETIC EFFECT OF HISTIDINE DIHYDROCHLORIDE IN ZEBRAFISH MODEL

Sumeet Yadav*, Surendra V., Kalpana Pathak, Abhishek Raj Joshi, Uday Raj Sharma, Suresh Janadri and Manjunatha P.M.

Abstract

The present study was intended to investigate the anti-obesity and antidiabetic effect of histidine dihydrochloride in Zebrafish. Obesity induction by the model: diet induced obesity in zebrafish and glucose induced hyperglycemia by the model: glucose induced hyperglycemia in zebrafish. The effect of Histidine dihydrochloride on diet induces obesity in zebrafish model were determined by body weight; lipid estimation- (TG, Cholesterol, HDL, LDL); histopathological of liver and the effect of Histidine dihydrochloride on glucose induced hyperglycemia in zebrafish model were determined by the fasting blood glucose level. All the result we found the significant. HDC drug showed significant effect by decreasing in the body weight, lipid profile estimation – TG, Cholesterol, HDL, LDL, Fasting blood glucose level. HDC drug shows the anti-obesity and antidiabetic activity. This data indicates that in-vivo treatment with the HDC drug anti-obesity and antidiabetic condition in the diet induced obesity and glucose induced hyperglycemia zebrafish model.

Keywords: Anti-obesity, anti-diabetic, body weight, HDC, glucose, hyperglycemia.