Abstract

A SCRUTINY ON ROLE OF REMDESIVIR IN COVID-19 PANDEMIC

Arya Lekshmii U. S.*, Sowparnika Treasa Sabu and Shaiju S. Dharan

Abstract

Background: The year 2020 begins with pandemic Covid-19 which is the infectious disease caused by SARS COV-2. The disease mainly affects the respiratory tract. The first case of respiratory tract illness was reported from Wuhan city in China. Researchers across the globe are carrying out various researches to develop a effective medicine for prevention and treatment of disease. Till now there is no standard treatment regiment available. A vaccine SPUTNIK-V was developed by the Russian scientists which is expected to provide immunity against SARS COV-2. Several antiviral as well as anti inflammatory agents were used as treatment regimen. Emergency use authorization of FDA approved the use of Remdisivir for the treatment of Covid-19 on 01 May 2020. The drug was authorized for emergency use in various countries like India, US, Singapore, Japan, Australia. Method: The review paper was prepared by referring research and review article from various sites like Pubchem, Pubmed, Google Scholar, European Medical Agency; Science Direct. Etc. Observation: Remdesivir is a drug with broad antiviral activity. It is Adenosine Triphsosphate Analogue which was developed for potential treatment of Ebola virus. Remdisivir is also active against Nipah respiratory Syncytialvirus. MERS-Cov. In various studies the drug has shown clinical improvement in patient as well as optimal safety profile was observed. Several studies are still continuing to picture out the efficiency and safety of Remdisivir in Covid-19 patients.

Keywords: SARS COV-2, Sputnik-V, Remdesivir, Adenosine Triphsosphate Analogue, Antiviral.