Abstract

SYNTHESIS AND CHEMICAL CHARACTERIZATION OF AYABIRUNGARAJAKARPAM-A HERBO-METALLIC SIDDHADRUG

Nagalingam Varnakulendran* and Veeriah Elango

Abstract

Background: This experimental research study dealt with the preparation and characterization of Ayabirungaraja karpam(ABK) which underwent various levels of purities to make it free from untoward effect. The sophisticated analysis of instruments were an important criteria in studying the surface morphology, the chemical bond present which indirectly correlates with the active form and also an important feature of the standardization of the drug. Objective: To prepare the drug in shastrial method and to focus with specific aim to establish chemical characterization studies of ABK with sophisticated instruments. Methods: The preparation and purification of ABK involves heating and drenching, impregnation and solar heating. The chemical characterization was carried out with EDS, FE-SEM, FTIR, XRD, XPS, XRF, TGDTA, AAS. Results: SEM analysis showed that the roughness morphology seen on the surface of ABK. EDS shows the presence of iron, silicon, aluminium, magnesium, sodium, carbon, oxygen etc. XRD analysis showed the indexed pattern of ABK sample which indicating the formation of Fe2O3, XRF analysis showed the presence of mineral like Fe, Si, Al, Mn, K, Cl, Cu and Zn. On the surface of the drug by XPS supports the confirmation of coating of organic molecules. TG-DTA analysis showed the view of change in the weight of the substance with respect to the temperature over a period of intervals. FTIR analysis showed the peak value which are functional group present in ABK. AAS showed the heavy metals like mercury, cadmium, arsenic, lead were present within the permissible limit. Conclusion: The toxic heavy metal free ABK pharmacologically act as well absorbent, adsorbent and biocompatible drug.

Keywords: Standardization, biocompatible, Adsorbent, heavy metals, Absorbent.