Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLE

Prince Srajal*, Dr. Arun Patel, Shailendra Kumar Patel and Shalini Kesharwani

Abstract

Oxadiazole is the heterocyclic compounds having one oxygen and two nitrogen atoms in a five membered ring. Their derivatives were containing antimicrobial activity against all the selected microbial strains. Oxadiazole ring named as azoxime (1,2,4-oxadiazole), Furazan (1,2,5-oxadiazole) has gained acceptance, as a consequence, the literature is full of the multiplicity of the name for this nucleus. The present work reports the synthesis and biological activities of some novel 1,3,4-oxadiazoles with the following prototype structure. Physicochemical properties perform a useful and resulting role for the logical study of a chemical moiety and help in the determination of melting point, boiling point and determination of pH of a compound, we have done all these studies for oxadiazole derivative. For the synthesis of 1,3,4-oxadiazole, we use two step method in the first step we synthesize semicarbazone by semicarbazide and in second step Cyclization of semicarbazones to synthesize 5-Substituted oxadiazoles.1,3,4-Oxadiazole, the heterocyclic nucleus selected for the present study has been established to possess the varied type of biological activity like sedative, hypnotic, anticonvulsant, anticancer, antibacterial, antifungal, antiviral activities, etc. We have also performed antibacterial, anti-fungal, and anti-convulsant activity which has been produced well desire result. The present results have revealed that synthesized 2-amino-5-aryl-1,3,4-oxadiazole analogues exhibited better antibacterial activity than antifungal activity.

Keywords: 1,3,4-Oxadiazole, Antimicrobial activity, Oxadiazolines, azoxime, CADD, QSAR.