Abstract

DESIGN, SYNTHESIS AND DOCKING STUDIES OF DERIVATIVES OF 1,4-DIHYDROPYRIDINE AS ANTI-BACTERIAL AGENTS

Keerthana Shanmugam*, M. Vijayabaskaran, R. Sambathkumar, S. Jayaraman and G. Rathinavel

Abstract

The prime motivation of the present work is to design a drug in such a way that it can be used clinically to treat the bacterial disease by inhibiting the enzyme targets of the bacteria. Among heterocyclic compounds containing six membered rings, the important constituents that are usually found in biologically active natural products are 1,4- dihydropyridines. 1,4-dihydropyridine is a six membered aromatic ring containing N at the 1st position, which is saturated at the 1st and 4th position. The most feasible position for substitution is 4th of the heterocyclic ring which exhibit various pharmacological activities such as calcium channel antagonist, antihypertensive, anti-inflammatory, antifungal, analgesic and antimicrobial actions. It also shows anti-leishmanial, anticoagulant, anticonvulsant, anti-tubercular, antioxidant, antiulcer, antimalarial, HIV-1 protease inhibition and antifertility properties. Keeping in view of the above facts, a series of 1,4- dihydropyridine derivatives were prepared from three compounds by the condensation reaction of ethyl acetoacetate, aromatic aldehyde and ammonium acetate at 80°C. It is performed by Hantzsch synthesis. The synthesized 1,4-dihydropyridines were docked and investigated for its anti-bacterial activity against Streptococcus pneumoniae, Staphylococcus aureus & E.coli.

Keywords: Heterocyclic compounds, 1,4-dihydropyridines, Hantzsch synthesis, Docking study, Anti-bacterial activity.