Abstract

SOLUBILITY ENHANCEMENT TECHNIQUES

Vijay Thakur, Shivani Dogra*, Shivani Verma and HemRaj Vashist

Abstract

Solubility is the property of a solid, liquid, or gaseous chemical substances called solute to dissolve in a solid, liquid, or gaseous to form a homogeneous solution of the solute in the solvent. The solubility of a substance fundamentally depend on the solvent used as well on temperature and pressure the extend of solubility of a substance in a specific solvent is measure as the saturation concentration. Solubility occurs under dynamic equilibrium, which means that solubility results from the simultaneous and opposing processes of dissolution and phase joining. Solubility is not to be confused with the ability may be dissolve or liquefy a substance only because of a chemical reaction. Aqueous solubility is the concentration of the aqueous phase, when the solution is in equilibrium with the pure compound in its usual phase. Solubility is based on the highest dose strength of an immediate release product. Various techniques have been used for the enhancement of solubility of poorly soluble drug which include physical and chemical modification of drug and other methods like particle size reduction, crystal engineering, salt formation use of surfactant and so forth. Solubility is the one of the important parameters to achieve desired concentration of drug in systemic circulation. Drug efficacy due to their poor solubility.

Keywords: Solubility, Drugs, Crystallization, Hydrotrophy.