Abstract

LITERATURE REVIEW ON DEVELOPING CARDIAC DISORDERS- A RISK DUE TO ANTICANCER DRUGS

Asheeta A.*, Hima C. S., Chitra C. Nair and Beena M. I.

Abstract

As in the current scenario advanced cancer treatment have contributed decreased cancer related mortality. But even then there are chances for cancer survivors to cardiovascular diseases. Unfortunately it is mostly due to the anticancer drugs especially due to anthracyclines, gemcitabine, cisplatin, alkylating-agents and kinase-inhibitors (KIs) such as ibrutinib. The major thing to discuss is patient may affected with hypertension, diabetes or heart failure which increase an individual's arrhythmia susceptibility. Combination treatments for cancers increased arrhythmia risk. It is very much important to reduce this risk through identification and prevention of this drug related problems. Future anticancer drug trials should consider all these things to minimize the mortality and morbidity relating these side effects.

Keywords: Anticancer drugs, Cardiac rhythm disorders, Anthracyclines, Gemcitabine, Kinase inhibitors.