Abstract

FORMULATION AND EVALUATION OF DICLOFENAC DIETHYL AMINE MICEROEMULSION INCORPORATED IN HYDROGEL

Sweta Tyagi*, A. Panda , Sagufta Khan

Technocrat Institute of Technology in Pharmaceutical sciences Bhopal.

Abstract

Transdermal delivery offer number of advantages over conventional systems. However, the major problem with transdermal delivery is skin which behaves as a natural barrier making difficult for most of drugs to be delivered into and through it. Microemulsions are low skin irritation, powerful permeation ability and high drug loading capacity. The low viscosity of microemulsion restrains its clinical application due to inconvenient use the problem of poor patient compliance, clinical application and stability can be overcome by formulating hydrogel thickened microemulsion using carbopol as a hydrogel thickening agent. Diclofenac diethylamine, a non-steroidal antiinflammatory drug (NSAID) is topically very effective. The aim of the present research work was to formulate hydrogel thickened microemulsion with good solubility, powerful permeation ability and suitable viscosity for the topical delivery of ibuprofen using eutectic mixture of camphor and menthol as oily phase and also the solvent for the diclofenac diethyl amine with good penetration enhancer and imparts cooling effect to the skin. Carbopol 940 was used as a hydrogel thickening agent. The drug was found to be soluble in oil phase (the eutectic mixture containing equal parts of menthol and camphor) was >160mg/ml. Pseudoternary phase diagrams were constructed to obtain an optimum formula for DDEA. The pH values of the prepared DDEA microemulsion varied from 5.71-8.03 that are within the acceptable range for skin preparations. And the pH of gel observed is 5.8, drug content, drug release and viscosities are varies according formulations.

Keywords: Diclofenac diethyl amine,menthol, camphor, tween 80, carbopol 940.