Abstract

ANTIDEPRESSENT ACTIVITY OF CUMINUM CYMINUM.L. BY CHRONIC MILD STRESS INDUCED RAT MODEL

K. Priyanka*, Y. Anil Kumar, K. Kumari and S. K. BIbI Ayesha

Abstract

Cuminum cyminum (Apiaceae) a herb collected from the Chirala region, A.P. India. Phytochemical studies of Cuminum cyminum, ethanolic fraction subjected to column chromatography and estimation of total flavanoid content and to evaluate antidepressant activity of methanolic extract of Cuminum cyminum. The plant powder was subjected to continuous hot extraction in Soxhlet Apparatus & extracted successively with methanol as solvent. The extracts prepared were tested for the type of chemical constituents present by known qualitative tests. Total chemical content of methanolic extract of Cuminum cyminum were done. In vivo Antidepressant activity of methanolic extract was evaluated using Tail suspension method(TST), Forced swimming test (FST) methods in physically depressed rats. Statistical analysis was performed by one-way analysis of variance (ANOVA) followed by the Tukey‟s test for multiple comparisons.

Keywords: Cuminum cyminum; Anti-depression activity, Tail suspension test, Forced swimming test.