Abstract

PIPERAZINE DERIVATIVES: A REVIEW OF BIOLOGICAL ACTIVITIES

*Mounika Perli and Dr. R. Govindarajan

Abstract

Piperazine is a vital organic scaffold that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring and also posse‟s four carbon atoms. This moiety can be found in a plethora of well-known drugs with various therapeutic uses, such as antipsychotic, antihistamine, antianginal, antidepressant, anticancer, antiviral, cardio protectors, anti-inflammatory, and imaging agents. Slight modification to the substitution pattern on the piperazine nucleus facilitates a recognizable difference in the medicinal potential of the resultant molecules. The article describes a variety of molecular designs bearing piperazine entity furnishing as an anthelmintic agent, anti inflammatory agent, as an anti microbial agent, anti convulsing agent, as an anti histamic agent.

Keywords: Piperazine, antihistamine, anti-inflammatory, an anthelmintic agent, anti inflammatory agent, as an anti microbial agent, anti convulsing agent.