Abstract

HISTOPATHOLOGICAL IMPACT OF ACETAMINOPHEN ON KIDNEY OF OREOCHROMIS NILOTICUS (NILE TILAPIA)

*Dr. Rema L. P. and Liji C. B.

Abstract

Acetaminophen is one of the most emerging pollutant worldwide. It is a non- prescription analgesic and antipyretic drug. It was a safe drug used in prescribed dose, but overdose may lead to renal failure. It was detected in our water bodies and also has harmful effects on aquatic organisms and experimental animals. In the present study fishes were exposed to sub lethal concentration of 1/5th and 1/10th of acetaminophen for 96 hours. A control was run along with it. Effect of acetaminophen on kidney tissues increased with overdose and longterm exposure. Fishes exposed to 1/5th of acetaminophen showed more tissue damage in kidney, compared to 1/10th of sub lethal concentration. Drug induced renal injury has become a major challenge. The result indicates that the acetaminophen at overdose cause nephrotoxicity in experimental fish. The major pathological changes observed in the regions of kidney are presence of pyknotic nuclei, necrosis, congestion, glomerular edema with decrease in bowman’s space etc.

Keywords: pharmaceutical pollution, acetaminophen, nephrotoxicity.