Abstract

ANTIARTHRITIC ACTIVITY OF CRUDE EXTRACT OF CLERODENDRUM PHLOMIDIS (L.) LEAVES IN FCA INDUCED ARTHRITIS IN RATS

Ravi V. Patel*, Rakeshkumar Jat and Jitendra O. Bhangale

Abstract

The present study was carried out to evaluate the antiarthritic activity of crude extract of Clerodendrum phlomidis leaves on FCA induced arthritis in rats. The petroleum ether, ethyl acetate and alcoholic extract was administered orally at a dose 100, 200 and 400 mg/kg, body weight from day 13 to day 21. Arthritis was assessed by various parameters such as body weight, arthritic score, paw volume and ankle diameter on day 0, 3, 6, 9, 12, 15, 18 and 21. At the end of study, animals were anesthetised and blood was collected for the estimation of various haematological parameters such as haemoglobin content, total RBA, WBC, ESR count, CRP level and TNF alpha level. There was a significant increase in body weight, reduction in arthritic score, paw volume and ankle diameter in PECP (200 and 400 mg/kg); EACP and ACP (400 mg/kg, p.o.) treated animals. Above findings were confirmed by haematological results as, significant improvement in the levels of Hb and RBC count, and suppressed WBC count, ESR count, CRP and TNF alpha levels found in PECP (200 and 400 mg/kg); EACP and ACP (400 mg/kg, p.o.) administered arthritic group. Our finding showed a significant antiarthritic activity of Clerodendrum phlomidis leaves against FCA induced arthritis in rats.

Keywords: Clerodendrum phlomidis, Rheumatoid arthritis, FCA.