Abstract

ENDOSULFAN CAUSES HYPERCHOLESTEREMIC IN MICE AND ITS BIOREMEDIATION THROUGH CURCUMA LONGA

Poonam Kumari*

Abstract

The wide use of agrochemicals in agricultural practice has caused severe health hazards to humans while their side effects have damaged the environment also. Endosulfan is an organochlorine insecticide effective against a wide range of pests of cereals, coffee, cotton, fruits, oilseeds, potato, tea and vegetables. Moreover, it is easily absorbed by the stomach, lungs and skin and exposure through any route can be hazardous. In the present study, Endosulfan was administered orally at the dose of 3.0 mg/Kg body weight per day to Swiss albino mice for 4 weeks. Upon 4 weeks Endosulfan pretreated mice group, Curcuma longa (rhizome extract) at the dose of 200 mg/Kg b.w per day was orally administered for 4 weeks to these groups to observe the ameliorative effect. Mice were sacrificed at each interval and their blood were collected for biochemical assay especially lipid profile. The lipid profile study showed inclination in the cholesterol level, LDL, and triglycerides level while declination in HDL level after endosulfan exposure but, upon curcuma longa treatment to the endosulfan treated group showed significant declination in the cholesterol level, LDL, and triglycerides level while inclination in cholesterol HDL level. Thus, from the above study it can be concluded that although the entrance of these hazardous pesticide into our body cannot be stopped but by the use of these medicinal plant extracts as potent antidote can solve the problem at much extent.

Keywords: Amelioration; Curcuma Longa; Endosulfan; Hypercholesteremic.