Abstract

TO EVALUATE THE EFFICACY OF A HERBAL FORMULATION OF CLERODENDRUM GLANDULOSUM (SYN. COLEBROOKIANUM) AND ALLIUM SATIVUM AS HYPOLIPIDEMIC AGENT

Sinam Ganapati Devi, Puspanjali Khound, Partha Pratim Sarma, Himangshu Sarma, *Rajlakshmi Devi and *Bishnu Prasad Sarma

Abstract

Clerodendrum glandulosum Lindl. is commonly used in traditional medicine for the management of various diseases including hypertension, dyslipidemia and diabetes without the full understanding of the scientific basis for its use. And, Allium sativum has been proven effective in the prevention and treatment of atherosclerosis, which is widely used as a food and medicine by people in daily life. This study sought to evaluate the efficacy of the herbal mixture or formulation of ethanolic extract of Clerodendrum glandulosum leaves and garlic cloves on lipid profile of hyperlipidemic wistar rats. The formulation was made in the ratio of CG:AS into 8:1. The rats were pre-treated with the formulation and synthetic hypolipidemic drug atorvastatin. Hyperlipidemia was induced by single intraperitoneal injection of poloxamer- 407(300mg/kg. body weight). Also, acute and sub acute toxicity tests were carried out on wistar rats using standard methods. At the end of the experiment, the animals were subjected to euthanasia and blood samples were separately collected through cardiac puncture. Anti- hyperlipidemic activity was measured in the plasma of rats by estimating the levels of total cholesterol (TC), LDLc, HDLc and Triglycerides (TG). It was observed that the levels of TC, LDLc, TG were significantly lowered in dose dependent manner and also observed that HDLc level was significantly increased. Results indicate that the formulation was able to positively regulate induced experimental hyperlipidemia by significant alteration in plasma lipid profiles as a prophylactic measure.

Keywords: Clerodendrum glandulosum, Allium sativum, poloxamer-407, hyperlipidemia, atherosclerosis, lipid profile, anti-hyperlipidemic activity.