Abstract

EXPLORING FORMULATION AND EVALUATION OF SIMETHICONE MEDICATED CHOCOLATE FORMULATION FOR ANTI- FLATULENCE EFFECT

Garima Sampurnanand Pandey*, Mayuri Tulsiram Patil, D. K. Vir, Prachi Mahendraprasad Pandey and Ramzan Abbas Pathan

Abstract

The target of study is to formulate and evaluate a nutritious simethicone chocolate with least number of side-effects and its interactions. Simethicone primarily acts in the stomach and intestinewhich lessens the surface tension of small number of bubbles resulting in coalescence into larger bubble leading to elimination of gas through flatus and belching. Chocolate/cocoa has been known for its good taste and proposed health effects from centuries. Most of the drugs are bitter or bland due to which oral administration of these drugs leads to patient incompliance especially in children. Cocoa which is the chief ingredient of many chocolate formulations was substituted with carob (Ceratonia siliqua) because cocoa containing formulation requires huge amount of sugar content and it contains caffeine causing stimulation of CNS. Although carob contains sweeteners naturally; contains no fat, no caffeine, no oxalates it becomes beneficial tremendously. The medicated chocolate was prepared by incorporating Simethicone into chocolate base which was made from carob powder, cocoa butter, peanut butter and was evaluated for general appearance, moisture content determination, fat bloom test, hardness test, its dimension, and stability in packaging material. Disintegration test was performed by using artificial saliva as its medium in order to note the time required to disintegratethe base and report the time at which the drug is released.

Keywords: Simethicone, Medicated chocolate, flatulence, Antiflatuence, Carob.