Abstract

PHARMACOLOGICAL ACTIVITIES OF SPONDIAS MOMIBIN L.: A REMARKABLE MEDICINAL PLANT

Nusrat Jahan Sugandha, Susmita Saha, Fahadul Islam, Syada Nishat Anjum, Ala Uddin, All An Shariah Brishti and A. K. Azad*

Abstract

Background: Spondias mombin L. is one of the most useful traditional medicinal plants. In rural areas a lot of people use Spondias mombin L. for treating indigestion, infections, lower back pain, angina, sore throat, malarial fever, congestion, pneumonia, flatulence, diarrhoea, dysentery and haemorrhoids. Aims: The aim of this study is to open up a new avenue for improving the medicinal uses of Spondias mombin L. peels selected primarily for the assessment of antioxidant and cytotoxicity potential. Methods: The antioxidant activity was determined using DPPH (1,1-diphenyl-2-picrylhydrazine) radical scavenging assay and cytotoxicity potential was regulate using Brime shrimp Lethality bioassay. Results: The antioxidant activity showed an LC50 of methanol extract as (66.29 μg/ml), where the LC50 values of standard Ascorbic acid showed (29.16 μg/ml), respectively as well as cytotoxicity potential showed LC50 of methanol extract as (1.66 μg/ml) where the LC50 values of standard vincristine was (0.25 μg/ml) as positive control, respectively. Conclusions: It is obvious from the above findings that, in various research models, Spondias mombin L. demonstrated considerable pharmacological potential. This would be a potential source of an isolating the lead compound to treat the healing of the a variety of diseases.

Keywords: Fruit peels, Ascorbic acid, DPPH, Vincristine sulphate, DMSO (Dimethyl sulfoxide), Artemia salina.