Abstract

DESIGN AND IN VITRO EVALUATION OF NOVEL IBUPROFEN SUSTAINED RELEASE MATRIX TABLETS BASED ON COMBINATION OF HYDROPHILIC AND HYDROPHOBIC MATRIX SYSTEM

*Patel Sunilkumar A., Patel Jitendra L.

Abstract

Hydroxypropyl and Ethyl cellulose are matrix polymer can be used in formulation of sustained release dosage form of slightly water soluble drug. It was decided to study the effect of these hydrophilic and hydrophobic polymers at different matrix polymer ratio, on release profile of drug from matrix formulation prepared using hydrophilic and hydrophobic matrix system and both matrix systems in different ratio used. Ibuprofen was considered as ideal drug for sustained release formulation. The sustained release matrix of Ibuprofen were prepared by wet granulation technique in differ matrix polymers ratio. Drug release study was carried out using BP apparatus 2 with pH 7 for 12 hr at 1 hr interval. During dissolution study different parameters such as effect of different matrix polymers ratio like HPMC: EC was carried out. The results of dissolution study showed that the release of drug from Matrix prepared from different ratio of both HPMC and EC gets more retarded than from HPMC and EC alone.

Keywords: Ibuprofen, HPMC K 4 M, EC, PEG 600, Lactose.