Abstract

IMPACT OF CNS DEPRESSANTS & NSAIDS MEDICATIONS IN FIBROMYALGIA DISEASE

Usha Verma*

Abstract

Fibromyalgia is an idiopathic, chronic pain syndrome defined by widespread nonarticular musculoskeletal pain and generalized tender points. Mood disturbance is common among patients with fibromyalgia (FM), but the influence of psychological symptoms on pain processing in this disorder is unknown. In this approach, some kind of manipulations are conducted to induce clinically relevant pain states such as hyperalgesia and allodynia in the experimental animal, and then, pain-associated behaviors are measured as indicators of pain. Recent findings regarding sleep architecture, immunology, and endocrinology have provided clues that may help in the understanding and resultant treatment of this entity. Women with fibromyalgia tend to present with an alpha-delta sleep anomaly, which when treated with a growth hormone secretagogue (GHS), reduces the rheumatological pain and restores slow-wave sleep architecture. Efficacy of test drugs on the said pain is finally evaluated. Diazepam and ibuprofen relieves anxiety and inflammation respectively in fibromyalgia. The selected NSAIDS and CNS depressants as a combination therapy are frequently used prescription agents for fibromyalgia. Though the above mentioned treatment profile is for fibromyalgia, antidepressants and NSAIDS are the more frequently used combination therapy for this disease.

Keywords: Fibromyalgia, Diazepam, Ibuprofen, NSAIDS, Hyperalgesia, Cold stress.