Abstract

SITE SPECIFIC TARGETED THERAPEUTICS FOR EFFECTIVE TREATMENT OF CANCER: A MINI-REVIEW

Neelam Sharma, Patel Parita, Shreyas Desai*, Umesh Upadhyay and Bhargavi Rathva

Abstract

Cancer is defined by uncontrolled growth of cells and the treatment options available include surgery, radiotherapy as well as chemotherapy. Non-specific distribution of anti-cancer drugs in the body and associated deadly adverse effects limits the use of chemotherapeutic drugs and their effectiveness. Thus, the aim of targeted site specific therapeutics is to deliver anti-cancer drug to the right site of tumour to minimize drug uptake by non-malignant cells. There are two major strategies for targeting know as passive and active targeting. The mini-review describes about both the targeting strategies, mechanisms, challenges, research outcomes and example of such delivery systems for the treatment of cancer.

Keywords: Cancer, chemotherapy, targeted therapy, site-specific, drug carrier, enhanced permeation retention, receptor targeting.