Abstract

COMMUNICATIONS BETWEEN PROTEINS AND GLYCOCONJUGATES IN ORGANISM INFECTED WITH COVID

Vladimir M. Lakhtin*, Mikhail V. Lakhtin, Valery Yu Davydkin, Stanislav S. Afanasiev, Vladimir A. Aleshkin

Abstract

Antipathogen and antitumor potential of metabolite-cellular lectin supersystem of human organism including key contributor lectin systems such as postbiotics, probiotic proteins, complement, protein hormones and angiotensin-renin systems were evaluated. Postbiotics possess a broad extremely perspective potential against different groups of diseases. They are characterized as a coupled system within a network recognizing glycoconjugates. Postbiotics act according to functioning metabolic axes within mucosal open cavities among different type tissues and organs. Lectin supersystem serves the ancient basis for stabilization, prolongation and improvement of protective action of such effectors as meta/postbiotics, prebiotics and drugs of glycoconjugate origin. The action of protective lectin system involves cofunctioning to other systems of recognition and effector action (antibodies, cytokines, complement, antibiotics, drugs for chemotherapy). The action of the supersystem recognizing viral and other pathogens directly or indirectly is described on examples of diseases accompanied with Covid. On the basis of protein-glycoconjugate relationships and interactions, factors and ways of designing antiviral vaccines are indicated. Prospects of protective supersystem constituents are discussed. Expression and modulation of different lectin type recognition systems as supersystem in organism can be considered as a new way for development of new criteria for health of individual or contingents of individuals at the level of cell-metabolite communications.

Keywords: postbiotics; Covid-19; SARS-CoV-1; SARS-CoV-2; diseases; lectin systems; glycoconjugates; complement; protein hormones; vaccines.