Abstract

REVIEW ARTICLE: SYNTHESIS, CHARACTERISATION AND INVITRO ANTI- MICROBIAL SCREENING OF NOVEL SCHIFF BASES

P. Syamala, N. Ashritha*

Abstract

A literature Survey of hydrazide Schiff bases showed that the Schiff bases were reported as more potent Anti-Microbial agent. The aim of work is to Synthesize new hydrazide Schiff bases and evaluate Anti- Bacterial activity. The derivatives are synthesized by equimolar quantities of ethyl-4-bromo benzoate, hydrazine hydrate and the resultant mixture is reacts with aldehyde leads to the formation of Schiff Bases. The substitute Schiff base moieties are previously different biological activities. Here we have synthesised some novel Schiff bases. The characterization and structural elucidation of these novel Compounds were carried by using spectral techniques like IR. The anti-Microbial Screening results presented in all the synthesised hydrazide Schiff bases exhibited significant anti-bacterial activity against the microbial Strains. All the synthesised Compounds were active against all tested micro organisms with a range of minimum inhibitory concentration (MIC) values. The results from anti bacterial screening clearly indicated that the compounds synthesised have shown good anti-bacterial activity with the standard drugs.

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