Abstract

ANTIDIABETIC ACTIVITY OF ETHENOLIC EXTRACT ALBIZZIA LEEBECK IN ALLOXAN-INDUCED DIABETIC RATS

*Shukla Neha, Joshi amit, Dubey B.K

*Department of pharmacology, TIT college of pharmacy, Bhopal, M.P

Abstract

Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and abnormalities in carbohydrate, fat and protein metabolism. It results from defects in insulin secretion, insulin sensitivity, or both. Chronic microvascular, macrovascular, and neuropathic complications The present study was carried out to evaluate the antidiabetic activity of Albizzia leebeck ethanolic leaf extracts in alloxan induced diabetic rats for 7 days. The oral administration of ethanolic leaf extract of Albizzia leebeck were found to have potent antidiabetic activity that reduces blood sugar level in alloxan induced diabetic rats. In this study, the antihyperglycemic effect of extract at 200mg/kg b.w.p.d were investigated. Glibenclamide was used as reference drug at 2.5mg/kg b.w.p.d. Fasting blood glucose, serum insulin and liver enzyme levels was evaluated in normal, diabetic and treated rats.

Keywords: Diabetes mellitus, Albizzia leebeck , Alloxan, Hypoglycemic Effect, Hypolipidemic Effect, Glibenclamide.