Abstract

EVALUATION OF ISOLATED PHYTOSTEROL FROM LEAVES OF HOLOPTELEA INTEGRIFOLIA (ROXB.) PLANCH FOR IT’S ANTIDEPRESSANT ACTIVITY IN EXPERIMENTAL ANIMALS

Ravindra C. Sutar*

Abstract

Background: Majority of scientific documentation suggested promine nt role of Phytosterols towards Antidepressant activity. The main objec tive of the work was to evaluate Antidepressant activity of Holoptelea i ntegrifolia isolated Phytosterol (HIIP) from petroleum ether extract (P EHI) of leaves of Holoptelea integrifolia (Roxb) Planch. Methods: The Antidepressant activity of different doses of HIIP (10 and 30 mg/kg-p.o.) was evaluated using Forced Swim Test (FST) in mice. Results: HIIP-30 mg/kg was more potent than HIIP-10 mg/kg for showing Antidepressant activity. Conclusions: The results indicate that HIIP shows Antidepressant activity which was dose dependent.

Keywords: Forced Swim Test, Holoptelea integrifoila Isolated Phytosterol Depression, Fluoxetine.