WJPR
World Journal of Pharmaceutical Research
( An ISO 9001:2015 Certified International Journal )
An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
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WJPR Citation
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| All | Since 2020 | |
| Citation | 8502 | 4519 |
| h-index | 30 | 23 |
| i10-index | 227 | 96 |
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Best Paper Award : Dr. Dhrubo Jyoti Sen
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Abstract
DEVELOPMENT OF SPECTROPHOTOMETIC METHODS FOR THE ESTIMATION OF WATER INSOLUBLE CALCIUM CHANNEL BLOCKERS USING HYDROTOPIC SOLUBILIZATION TECHNIQUE*Naresh Kalra, Suresh Choudhary
Department of Pharmaceutical sciences, Alwar Pharmacy College, IET, North Extension M.I.A, Alwar, India.
Abstract The present study deals with a rapid, simple, accurate, and rugged UV spectrophotometric methods have been developed for the estimation of some water insoluble calcium channel blockers using hydrotropic solubilization phenomenon in pure and as well as in dosage forms. The calibration graphs were linear in the 2-20μg/ml concentration range (r>0.999) for Nimodipine. The detection was made on 346nm & 357nm in methanol or 1% urea. The method was validated according to ICH guidelines by performing linearity, accuracy, precision, limits of quantitation and selectivity. The results show the method is suitable for its intended use. Keywords: Nimodipine, method validation, simultaneous spectrometric analysis. [Full Text Article] [Download Certificate] |
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